The Banned and the Banished series by James Clemens
Anteros series by Allan Cole (my favorite books center around the one-handed, eyepatched lesbian heroine)
Necroscope series by Brian Lumley (Horror/Sci-Fi and by far my favorite take on the vampire mythos)
The Snow Queen by Joan D. Vinge (evil space queen with a genetic twin? yesplz! - The upcoming Wachowski film, Jupiter Rising, has a plot similar to the book.)
The Cycle of Fire trilogy by Janny Wurts (the first fantasy series I've read and still one of my favorites)